Fiorentina 1-1 Tottenham Nacer Chadli slotted a penalty for the English side in the 37th minute, but Federico Bernarderschi (59') netted the equaliser in the first leg of their last-32 tie.
Anderlecht 1-0 Olympiakos Anderlecht secured a home victory over Olympiakos thanks to Kara Mbodj's 67th-minute strike. Saint-Etienne 3-2 Basel A 77th-minute goal from Jean-Christophe Bahebeck saw the hosts win the first leg. Moustapha Bayal (9') and Kevin Monnet-Paquet (39') gave the French side a two-goal lead before Walter Samuel (44') and Marc Janko (56') levelled matters. Dortmund 2-0 Porto The hosts claimed a comfortable win after goals from Lukasz Piszczek (6') and Marco Reus (71'). Sevilla 3-0 Molde Fernando Llorente (35', 49') netted a brace for the hosts before Kevin Gameiro put the result beyond doubt in the 72nd minute. Villarreal 1-0 Napoli Denis Suarez (82') produced the solitary strike to secure the win for Villarreal. Sion 1-2 Sporting Braga Nikola Stojiljkovic (13') put Braga ahead before an equaliser from Moussa Konate (53'). Rafa Silva (61') provided the winner for the travelers. Galatasaray 1-1 Lazio Sabri Sarioglu (12') put the hosts in front but Sergej Milinkovic-Savic (21') responded quickly to level matters. Marseille 0-1 Athletic Bilbao Aritz Aduriz (54') produced the only goal of the game as Athletic clinched an important away win. Shakhtar 0-0 Schalke Neither side could find the decisive strike as they played out to a goalless draw. Sparta Praha 1-0 Krasnodar The home outfit take the advantage into the second leg thanks to Lukas Julis' (64') strike. Sporting Lisboa 0-1 Leverkusen The Bundesliga outfit came away with the victory after Karim Bellarabi (26') netted the vital goal. Valencia 6-0 Rapid Wien The Spanish side demolished their visitors as Santi Mina (4', 25'), Daniel Parejo (10'), Alvaro Negredo (29'), Andre Gomes (35'), and Rodrigo (89') got on the scoresheet. 
