Senegal maintained their winning start in Group I after thrashing Eswatini at Mavuso Sports Centre on Sunday afternoon.
Famara Diedhiou grabbed the headlines after netting a hat-trick while Pape-Alioune Ndiaye bagged Senegal's fourth late on.
Fganelo Mamba bagged Eswatini's only goal and was later sent off.
Goals from Fahad Bayo and Emmanuel Okwi guided Uganda to a 2-0 victory over Malawi on Sunday afternoon.
Nigeria made it two wins from two games in Group L after thrashing Lesotho 4-2 at Setsoto Stadium on Sunday evening.
Alex Iwobi and Samuel Chukwueze netted in the first half for the visitors after Masoabi Nkoto put Lesotho ahead in the 11 minute.
Vitcor Osimhen bagged a brace to extend Nigeria's advantage before the hosts got a second goal through Chidozi Awaziem's own goal in second-half stoppage time.
Ngoumo Ngameleu's 71st minute strike was enough to hand Cameroon a 1-0 win over Rwanda at the Stade Regional Nyamirambo.
As a result, the Indomitable Lions have jumped to of Group F with their first win, while Rwanda are rooted to the bottom.
Issiaga Sylla and Kante netted in either half to guide Guinea to a 2-0 victory over Namibia in Group A.
The win moves Guinea top, while Namibia sit in third spot.
Gabon registered their first win in Group D with a 2-1 victory over at the Stade de Franceville.
The hosts raced into a two-goal lead thanks to strikes from Denis Bouanga and Aaron Boupendza.
Angola did pull a goal back through Yano in the 85th minute, but Gabon were able to hold out for victory.
Benin 1-0 Sierra Leone
Chad 0-2 Mali
Congo 3-0 Guinea Bissau
South Africa 1-0 Sudan
