FC Barcelona 1-1 Real Betis
FC Barcelona were unable to take full advantage of Real Madrid's slip-up after dropping points against Real Betis.
Barca coach Hansi Flick surprisingly left Raphinha on the bench after the midweek Copa del Rey action.
The Catalan giants got the breakthrough after just seven minutes when a well-worked passing move ended with Gavi slotting home against his former team.
Betis weren't behind for too long as defender Natan rose highest to head home Giovani Lo Celso's in-swinging corner.
Blaugrana threw everything forward in the second half but were unable to find the winning goal, leaving the side to settle for a point.
As a result, Flick's men only extend their lead over Los Blancos to four points while Betis move up one spot into fifth.
Real Madrid 2-1 Valencia
Real Madrid's title chances suffered a blow after a surprise 2-1 defeat to Valencia at the Santiago Bernabeu.
Carlo Ancelotti's men came into the side on the back of a 4-4 draw against Real Sociedad in the Copa del Rey on Tuesday, as goalkeeper Franz Gonzalez got a rare start as Andry Lunin was suspended.
Los Blancos did not get off to a good start as Mouctar Diakhaby found the back of the net after 15 minutes to give Los Che the lead, just two minutes after Vinicius Junior missed a penalty.
The hosts had to wait until the 50th minute to get back on level terms, as Vinicius Junior made up for his penalty mis by getting his name on the score-sheet after being set up by Jude Bellingham.
With the game seemingly headed for a draw, Valencia popped up with the winning goal in the fifth minute of time added on thanks to Hugo Duro's eighth league goal of the season.