Kamohelo Mokotjo's Brentford were dumped out of the FA Cup after a 1-0 loss to Premier League outfit Leicester City at Griffin Park.
Kelechi Iheanacho got the game's only goal as early as the fourth minute to send the Foxes into the fifth round.
Mokotjo, meanwhile, played only played the opening 45 minutes before being replaced by Joshua Dasilva.
Norwich City secured a fifth round spot despite struggling in the English Premier League after edging fellow top flight side Burnley 2-1 at Turf Moor.
Grant Hanley and Josip Drmic netted two goals within four minutes just before the hour-mark for City and although Erik Pieters pulled a goal back for the Clarets with 18 minutes remaining, it was not enough in the end to avoid defeat.
Sheffield United booked a spot in the fifth round after beating second tier side Millwall 2-0 at The Den.
Muhamed Besic broke the deadlock for Sheffield in the 62nd minute before Oliver Norwood secured the win with the second goal six minutes before time.
League One side Oxford United earned a replay against Premier League giants Newcastle United after a goalless draw at St. James' Park.
Southampton netted three minutes before time to force a replay against Tottenham Hotspur after a 1-1 draw at St. Mary's Stadium.
Son Heung-Min fbroke the deadlock for Spurs two minutes before the hour-mark but Sofiane Boufal denied Jose Mourinho's charges entry into the fifth round with the equaliser for the Saints in the last three minutes.
Ten-man West Bromwich Albion booked a spot in the fifth round after edging top flight side West Ham United 1-0 at the London Stadium.
Conor Townsend gave West Brom a dream start with the opener in the ninth minute but the Championship log-leaders had a scare in the 72nd minute after they were reduced to ten men following the dismissal of Semi Ajayi for a second booking.
