Milan 6-0 Shkendija
AC Milan showed Shkendija no mercy as they romped to a 6-0 win in their first leg tie at the San Siro.
The hosts raced into a three-goal lead in the first half thanks to a brace Andre Silva and a strike from Ricardo Montolivo.
New signing Fabio Borini bagged the fourth goal in the 67th minute, before Luca Antonelli made it 5-0 a minute later. Montolivo rounded off the scoring for Milan with his second in 85th minute.
Everton 2-0 Hajduk Split
Everton looks set to progress to the next round of qualifiers, after they recorded a 2-0 win over Hajduk Split at Goodison Park.
Michael Keane opened the scoring after 30 minutes, before Idrissa Gueye doubled the hosts' lead with Wayne Rooney picking up the assist.
Ajax Amsterdam 0-1 Rosenborg Ajax Amsterdam suffered a setback in their qualifying campaign after losing 1-0 to Rosenborg on home soil.
Nigerian winger, Samuel Adegbenro popped up with the game's only goal in the 77th minute.
Vardar 2-0 Fenerbahce Turkish giants Fenerbahce are on the brink of missing out on progression to the next round, after they suffered a 2-0 defeat to Vardar at the Nacionalna Arena Filip II Makedonski.
Panathinaikos 2-3 Athletic Club Athletic Bilbao came back from two goals down to secure a 3-2 win over Panathinaikos on Thursday evening. Robin Lod and Bryan Cabezas put the hosts two goals up, before a strike from De Marcos and Aritz Aduriz's brace secured the win.
Other results: Domzale 1-1 Olympique Marseille Club Brugge 0-0 AEK Athens PAOK 3-1 Ostersunds Dinamo Zagreb 1-1 Skënderbeu Korce FH 1-2 Sporting Braga