Manchester United 1-3 Brighton and Hove Albion
Manchester United's 20-game unbeaten run at Old Trafford came to an end after losing 3-1 to Brighton and Hove Albion on Saturday afternoon.
Erik ten Hag handed a debut to Sergio Reguilon at left-back while striker Rasmus Højlund made his first start by replacing Anthony Martial.
It was the visitors who got the breakthrough against the run of play on 17 minutes when Danny Welbeck slotted home from close range against his former side.
United thought they had the equaliser a few minutes before the break when Hojlund turned home Rashford's cross, however the goal was ruled out after the ball deemed to have gone out before the cross.
The lead was doubled ten minutes into the second half when Pascal Gross did well to carve out space before burying the ball into the bottom corner.
It got worse for the home side with 20 minutes left on the clock as Tariq Lampety did well to pick out Joao Pedro, who sent a first-time finish into the far corner for the third goal.
West Ham United 1-3 Manchester City
Manchester City reclaimed top spot after rallying from behind to defeat West Ham United 3-1 on Saturday afternoon.
The Hammers found the breakthrough in the 36th minute, with new signing James Ward-Prowse finding the back of the net with an impressive header.
City got back on level terms shortly after the halftime break when new signing Jeremy Doku got his first goal for the club after being set up by Julian Alvarez.
The Citizens completed the turnaround in the 76th minute when Bernardo Silva found the back of the net with his first league goal of the campaign.
It wouldn't be a Man City win without Haaland getting on the score-sheet, as the Norwegian rounded off the scoring in the 86th minute.
Tottenham Hotspur 2-1 Sheffield United
Tottenham Hotspur staged a late comeback to sure a 2-1 victory over Sheffield United on Saturday afternoon.
Gustavo Hamer gave the visitors the lead with a well-taken finish in the 74th minutes.
However, Richarlison pulled Spurs level with a neat header in the 98th minute before Dejan Dejan Kulusevski grabbed the winner for the hosts two minutes later with a lovely finish.
Aston Villa 3-1 Crystal Palace
Aston Villa battled back to secure a 3-1 victory over Crystal Palace at Villa Park.
The Eagles found the breakthrough two minutes after the halftime break, with Odsonne Édouard grabbing his third league goal of the season.
Villa managed to snatch a point with three minutes left on the clock courtesy of a superb strike from Jhon Duran, before Douglas Luiz neted the winning goal in second-half stoppage time from the penalty spot.
Leon Bailey rounded off the scoring for Unai Emery's charges in the 11th minute of time added on after some good work by Moussa Diaby.
Fulham 1-0 Luton Town
Fulham resumed Premier League action with a 1-0 win over winless Luton Town at Craven Cottage.
Brazilian striker Carlos Vinicius came off the bench to score the all-important winning goal for the home side.
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